The Amazing Therapeutic Effects of Vitamin B3

I recently received a call from a lady who suffers from aggravating pain in various parts of her anatomy. She had just returned from a visit to her primary care doctor who didn’t spend much time explaining why she was in such pain. She doesn’t like to take medication and her doctor wasn’t very pleased with that decision so he decided that he could do nothing else for her and suggested she might benefit from a referral for pain management. She was deeply saddened by this exchange even though the physician scheduled her for a full blood workup and physical in 60 days. She called me to ask what nutritional products should she take in the meantime.

This is a typical story that I receive on a weekly basis from individuals who are living with joint pain, inflammation, and various degrees of immobility or some form of depression, which brings me to this blog post. Inflammation is part of a very complex response to the tissues of the body to harmful stimuli such as irritants, damaged cells, bacteria, viruses, fungi and parasites or pathogens.  Getting an upper hand on inflammation or most maladies requires a lifestyle change—a decision to change, a commitment to specific actions for life. Many of us seek some type of relief from a particular symptom or a set of symptoms as opposed to seeking wellness strategies which is a continuous, every day, and dynamic set of specific activities to feel vibrant, energized, and alive to be able to do the things one is called to do while occupying this amazing planet.

So, let us turn our attentive eyes on the third vitamin that was discovered in the “B” complex family of vitamins. B3 or Niacin comes in multiple forms as nicotinic acid, niacinamide or nicotinamide as well as inositol hexaniacinamide.  Niacinamide (B3) is a water soluble vitamin that functions metabolically as a component of two very important coenzymes: one being nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). These two niacin containing coenzymes are involved in more than 200 different reactions in the metabolism or life sustaining chemical transformations of carbohydrates, amino acids and fatty acids making it a critical part of supplying energy to and maintaining the function of every cell in your body.  

One of the most important problems we begin to experience as we increase in age are the challenges with the normal function of our joints—-they become inflamed and we call it arthritis (“arth”=joint and “itis”=inflamed). We have accepted, without question, the idea that achy joints, pains in the various parts of the body and a loss of flexibility as the typical signs of getting older. The result of this type of thinking, or I should say, the result of the lack of activity associated with that type of thinking, has created a multibillion dollar market of prescription and over the counter medications in the attempt to control and /or alter this inflamed condition. On the other hand, researchers have known for decades that a large percentage of both minor and crippling joint pain as well as challenges with normal mobility could be corrected by consuming niacinamide or the vitamin called B3.  Continued research into this vitamin revealed that inadequate amounts of B3 in the diet could be directly responsible for a whole list of physical and mental issues that were considered a normal part of the aging process (8).

This list consisted of nervous system impairment that resulted in depression, anxiety and personality changes, impaired balance, overreaction to noise, fear of being hurt and abnormal skin sensations.

The disease originates in your gut, with GI tract symptoms preceding dermatitis, and the condition is well known to be associated with malnourishment and the “poor man’s diet” consisting primarily of corn products. Pellagra was epidemic in the American South during the early 1900’s, and we just might be dealing with a similar epidemic of malnutrition today.

A quote from the book Nourishing Traditions: The Cookbook that Challenges Politically Correct Nutrition and the Diet Dictocrats reads:

“The clinical description of the typical poor Southerner, any time between about 1900 and 1940, comes alive in the novels of William Faulkner–the brooding sullenness, suddenly shattered by outbursts of irrational anger, persecution, mania, the feeling of people living in a cruel and demented world of their own… Doctors knew very well that diet was at the bottom of all the misery they saw around them, and that disease could be kept at bay by a balanced food supply…”

Hartke continues:

“… Barbara Stitt, an author who once worked as a probation officer… found that changing the diet of ex-offenders eliminated the hostility and other symptoms that would lead them to act out in a criminal fashion. Her book is aptly titled, Food & Behavior: A Natural Connection and her work seems to confirm the findings of Dr. Weston A. Price on nutritional injury and the role it plays in juvenile delinquency and adult crimes.”

A review of Barbara’s book mentions her concern about reactive hypoglycemia, sub-clinical pellegra and vitamin B deficiencies being at the root of violent criminal’s actions. Check out this revealing quote from the review: ‘The startling part of sub-clinical pellagra, like hypoglycemia, is that the symptoms also mirror those of schizophrenia, a problem so widespread that those who suffer from it occupy one out of every four hospital beds in the United States.'”

Dr. Stitt’s book also discusses other vitamin B deficiencies, such as B1, B2, B6 and B12—all of which have an uncanny ability to produce symptoms of neuropsychiatric disorders.


Symptoms of vit B deficiency

                Credit: Food and Behavior by Barbara Stitt (10) (11)


A bit of history may be in order at this point. Before 1941, bread, flour and cereals were made from highly processed nutrient depleted white flour. Because it was a voluntary program, some manufacturers started enriching foods with the “B” complex vitamin which included niacinamide (B3). By 1943 this program had become compulsory and it remained that way throughout World War II. Once niacinamide was introduced into the diet many people having health problems mentioned here began to get better. Researchers also found that there were four problems that persisted even after the enrichment program was implemented. These four problems were loss of balance, depression, decreased muscle strength and work capacity, and impaired joint function. What’s very alarming is that these problems are so common in our society that we just write it off as the inevitable byproducts of the aging process. But it has also been proven, many times over, that the addition of vitamin B3 could correct these problems. It was found that approximately 70% of patients who ingested up to 300 milligrams of niacinamide demonstrated a greater working capacity and less fatigue after only 30 minutes and muscle strength improved in approximately 30% of the patients. What is even more compelling is that the continuous daily ingestion of niacinamide showed more pronounced improvements.

Vitamin B3 is an amazing supplement but, do remember, it isn’t a cure-all for depression, or any other ailment for that matter. However, in many cases it can lead to significant improvements.  Niacinamide has been shown to go a long way in both preventing and minimizing arthritic joints.

Dietary sources of niacin and tryptophan include:

  • lean meats
  • poultry
  • fish
  • organ meats
  • brewer’s yeast
  • milk
  • legumes
  • mushrooms
  • sunflower seeds
  • avocado
  • peanuts & peanut butter.

Niacin is also synthesized by intestinal bacteria.

In closing, while the use of niacinamide may seem simple, please don’t let this simplicity downgrade its effectiveness. When the right niacinamide is taken correctly, it can cause some amazing psychological and physical transformations.  



  1. The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular energetics, and aging Oblong JE.DNA Repair (Amst). 2014 Nov;23:59-63. doi: 10.1016/j.dnarep.2014.04.005. Epub 2014 Apr 30. Review.
  2. Natural Medicines Comprehensive Database Methodology
  3. Randomnized, double blinded, vehicle controlled, split face study to evaluate the effects of topical application of a Gold Silk Sericin/Signaline complex on biophysical parameters related to skin aging
  4. Niacin-respondent subset of schizophrenia-a therapeutic review. Xu XJ, Jiang 65. Eur Rev Med Pharmacol Sc 2015; 19(6): 988-97
  5. Relationship between Niacin skin flush response and essential fatty acids in schizophrenia. Messamore E. Prostaglandins Leuket Essent Fatty Acids. 2003 Dec;69(6) 413-9 Review
  6. Natural treatments for osteoarthritis. Gaby AR Altern /med Rev. 1999 Oct. 4(5): 330-41. Review
  7. Enhancing the inhibitory effect of nicotinamide upon collagen II induced arthritis in mice using N-acetylcysteine Published on Sep 3, 2012
  8.… Internationally renowned natural health physician and founder Dr. Joseph Mercola interviews Dr. Andrew Saul about niacin.
  9. Whole and Natural Foods Aug 24, 2012
  10. Barbara Reed Stitt Author:Food & Behavior – Nutritional Guidelines for Correcting Behavior – DVD – ‘Impact of Healthy Foods on Learning and Behavior -.
  11. Barbara Stitt’sFood & Behavior Reviewed by Jay Banks

About the Author Dr. Budweiser

Dr. Budweiser is dedicated to the belief and philosophy that the mission of the medical industry should be to assist people with attaining health freedom. With more than 20 years experience as a chiropractor and a 30-year history in nutrition and as an international speaker, he travels the world sharing his knowledge on health, wellness and abundance. As a neuro-musculo-skeletal expert, he is an expert in the human frame and wellness and has been wildly successful in using The Weiser Living concept to help others regain their health and wholeness.

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